A Greek philosopher Heraclitus (500 BC) once said, “No man ever steps in the same river twice, for it’s not the same river and he’s not the same man.” Dynamic development of self-organizing systems, humans, is highly plastic, lifelong, affected by multiple interacting forces, and multidimensional with multiple directions. After we recognized the fact that our development goes through multiple stages, we started recognizing that those stages can be different if some environmental factors are changed. Our physical body changes from the day one to the last day and alone with physical changes we go through mental changes, which can be less or more noticeable. We noticed that sometimes children can mature physically faster or their cognitive development can be slightly different from previous generation. We are starting noticing that in previous generations’ creativity and emotional sensitivity was not age related, but as social environment changes, age might become more leading factor. At same time we noticed that such small change in social environment as attachment to certain religious traditions can change creative potential for a few generations, which can lead to stagnation or rapid development of whole human civilization and become a reason for change of the climate on the whole planet… Heraclitus’ point was that strife and change are natural conditions of the universe. Integrative Physioepistemological model allows observe change in one dimension and follow changes in other dimensions, while those changes could be multidirectional.
Multiple studies have provided evidence of physiological brain’s states that directly correlate with mental states. Complex adaptive system, such as human civilization, delivers challenge of discovering and observation of whole complexity, because we are naturally inclining to simplify our explanation of complex events. The view on mental state in conjuncture with multiple dimensions entirely changes way we perceive the environment. Perceptive changes in the environment activate polygene, which can invoke the adaptive processes not only in individual, but in whole community. All together, it is related to change in mental state, which could be called metamorphosis of neuronal networks in the brain and qualitative change in robust communications and associations between them. Despite of the whimsy idea that metamorphosis of any mental state disconnected from physiological conditions of the brain, it is very challenging to provide enough evidence otherwise, because the finite time periods within similar systems could be different and dependence of outcome on multidimensional factors create illusion of systematic disintegration. Such change entirely changes way we perceiving the environment and invoking the adaptive processes to such changes. Environmental changes produce physiological stress, which involves two-way communication between the brain and all bodily systems, such as cardiovascular, immune, and other systems via neural and endocrine mechanisms. The physiological changes in brain structures such as hippocampus, amygdale, and prefrontal cortex include stress-induced structural remodeling, which alters behavioral and physiological responses. Such remodeling is a basis for metamorphosis of mental states. Release of different neuromediators and neuromodulators (such as glucocorticoids for example) can have effects on many systems and processes – from change in brain structure and transformation of mood to gastrointestinal activity and food intake control. We just started realizing that events in early life affect how the brain responds to environmental changes throughout adult life and influence the aging process trough all lifespan. Complex morphology of the brain and its’ interaction with environment produces constant metamorphosis of mental states in multiple dimensions and it could propagate in multiple directions simultaneously.