Physioepistemology Centered Evidence-based Education – Placing neuroplasticity in the center of newly developed educational methodologies require use of the insights from the studying of the brain functions and cognitive processes to investigate educationally inspired questions. More importantly, it changes direction of the neuroscientific approach in education to totally opposite direction: from extracting information from the brain, to delivering information to the brain and assisting in formations of tools this information processed. In contemporary speed of new knowledge discovery, traditional methods of education falling behind in delivery updated increased amount of information. The assessment of acquired knowledge during the educational process becomes available for outsourcing to new technologies, which might exclude human bias it all. Most time consuming part of educational process is time spend on learning new skills. New high effect-size methods are related to effective way to deliver higher level of complex information with decreased time of skill development.